what does liver attenuation mean

4 How big should a liver lesion be to be benign? information is beneficial, we may combine your email and website usage information with is mri with contrast needed or regular mri suffice. American journal of roentgenology. Visualized portions of the liver are homogeneous in echogenicity. evaluated without intravenous contrast, for example in the right hepatic Accessed April 12, 2021. What is the difference between grade 1 and grade 2 fatty liver? Your provider may monitor them by repeating imaging. a : a lessening in amount, force, magnitude, or value : weakening Sound can travel thousands of kilometers in this planar acoustic waveguide with little attenuation. What is hepatic lobe lesion? Liver adenoma, a rare liver tumor. (a) B-mode image. privacy practices. Hepatic steatosis is defined as pathologically elevated liver fat content and has many underlying causes. Fatty liver is also known as hepatic steatosis. Accessed April 12, 2021. We offer this Site AS IS and without any warranties. https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/8340. The treatment and prevention of liver lesions usually depend on the extent (stage) of the liver lesion. Hepatic steatosis is characterized by the buildup of fat in the liver; however, cirrhosis involves the development of scarring on top of healthy tissue. Cleveland Clinic Cancer Center provides world-class care to patients with cancer and is at the forefront of new and emerging clinical, translational and basic cancer research. The value of attenuation in normal liver was estimated as 0.52 +/- 0.03 dB/cm/MHz, measured at 3 MHz. A person can remain asymptomatic for years, although 57% of those with the condition will develop symptoms every year. No: 395, Sarojini Naidu Road, 1 The majority of liver lesions are benign (not harmful) and dont require treatment. please tell me what this means ? In severe cases of fatty liver, intrahepatic vessels may appear hyperattenuated relative to the fat-containing liver tissue (,17). Created for people with ongoing healthcare needs but benefits everyone. Am. The diagnostic standard of reference is biopsy with histologic analysis, but fat deposition in the liver may be diagnosed noninvasively with US, CT, or MR imaging if established criteria are applied. They may recommend specialized testing or monitoring to check for changes that require additional care. Fatty liver disease means you have extra fat in your liver. A CT scan was then done from my lower chest down. The LAI between -10 and 5 HU correlated well with macrovesicular steatosis in the mild-to-moderate range of 6%30%. Advertising revenue supports our not-for-profit mission. I am 62 year old male. AST. 8. Jacobs JE, Birnbaum BA, Shapiro MA et-al. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/benign-liver-tumors/#information-for-the-newly-diagnosed), (https://patient.info/doctor/benign-liver-tumours), (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338186/). Early diagnosis and prevention from. Other liver function tests measure enzymes that liver cells release in response to damage or disease. The falciform ligament sort of divides parts of the liver, and it's possible even that some of what is being seen is artifactual, meaning just some shadowing due to the crossing of the planes. However certain liver lesion or tumor can become malignant (cancerous) posing higher risk and requires surgical interventions for treatment. Screen for liver infections, such as hepatitis, Monitor the progression of a disease, such as viral or alcoholic hepatitis, and determine how well a treatment is working, Measure the severity of a disease, particularly scarring of the liver (cirrhosis), Monitor possible side effects of medications. Nonsteroidal anti-inflammatory drugs (NSAIDs)Aspirin, ibuprofen, and naproxen sodium can cause toxic liver disease if you take too much of the drug or take it with alcohol. The density of the tissue is in proportion to the attenuation of the x-rays which pass through. If you continue to use this site we will assume that you are happy with it. Uniform attenuation in liver. What are the symptoms of fatty liver disease? The CT attenuation value is defined as the radiodensity of each material and is expressed in HUs, in which the radiodensity of distilled water at the standard pressure and temperature was defined as 0 HU, whereas that of air was defined as -1000 HU. Do I have liver cancer? Its very rare in the U.S. Benign liver lesions usually dont cause any symptoms. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Mayo Clinic is a not-for-profit organization. A modified real-time sector scanner incorporating an online attenuation measurement method was used. American Liver Foundation. The left lobe is smaller and more flattened than the right. https://www.uptodate.com/contents/search. Most liver metastases are hypovascular and as a result are hypodense on CT in comparison with normal liver parenchyma during the portal venous phase (PVP). In cases like this I sit down with the radiologist who interpreted the ct scan and ask advice as to possible diagnosis, how concerning is the lesion, Attenuation is like density on a CT. A high attenuation tissue like bone, will appear white on a CT, whereas low attenuation (less dense substances l Dr. Frank Kuitems and another doctor agree. This website uses cookies to improve your experience while you navigate through the website. Accessed April 12, 2021. In addition, liver parenchymal attenuation in CT may be affected by some factors, including the presence of excess iron and glycogen in the liver and the certain drugs such as amiodarone and methotrexate, acute hepatitis or acute toxic hepatic injury and cirrhosis[15,39,40]. Approach of the Patient with a Liver Mass. lesion in the liver which is brighter(echogenic) than normal liver.Typically in young patients it turns out to be a benign hemangioma, which needs no Dr. Heidi Fowler and another doctor agree. Definition. Total protein. Complication can develop after 5 to 10 years, though it more commonly it takes 20 to 30 years. A liver lesion can be caused due to various underlying health complications. Tissues like air and water have little attenuation and are displayed as low densities (dark), whereas bone has high attenuation and is displayed as high density (bright) on CT. Mergo PJ, Ros PR, Buetow PC et-al. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. lipase elevated 400 dr didnt seemed concerned but i am scared. This content does not have an Arabic version. These cookies will be stored in your browser only with your consent. The physiologic attenuation of liver parenchyma at unenhanced multidetector CT varies interindividually between 55 and 65 HU. This can be due to a number of things ranging from technical difficulties with the machine to different abnormalities of the liver. This relationship was also significant after adjustment forage, gender, BMI, history of diabetes, smoking, and physical activity. What does diffuse liver mean? In people who already have nonalcoholic fatty liver disease, regular coffee drinking lowers the odds of developing cirrhosis. Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with SunAgri and INRAE in Avignon between 2019 and 2022. Diffuse disease of the liver: radiologic-pathologic correlation. Khalil et al. All rights reserved. 4. Areas of high attenuation (visually as opaque as bony structures) in an abnormality on CT scans can be an important clue to the correct diagnosis. Certain foods and medications can affect the results of your liver function tests. Possible causes include: The symptoms you experience depend on the type of liver lesion. You may feel a quick pain as the needle is inserted into your arm and experience some short-term discomfort at the site after the needle is removed. LAI greater than 5 HU correlated with macrovesicular steatosis of <5%. Weight Loss. (like a third breast almost! Dual phase hepatic CT: influence of scanning direction on liver attenuation. Kashyap PC (expert opinion). I had a MRI done that showed, the nonspecific fatty infiltrate of the left rectus muscle (again) , this time in addition: "fluid-fluid" level within the gallbladder, either gallbladder sludge or gallstones, slightly thickened posterior fundal gastric wall, and rib pathology is a consideration? Mayo Medical Laboratories. could sle serositis cause ? 5.6 in. In the liver, most low attenuation lesions are hemangiomas, which are benign, however your Dr can best determine if other risk factors or findings (cirrhosis, hepatitis etc,) warrant further evaluation of your lesion. For diagnostic purposes, liver masses should be divided into those occurring with and without cirrhosis. The high attenuation is most often caused by calcification, but may also be due to iodine, barium, or radiopaque foreign bodies. Most people don't have serious reactions to having blood drawn. What does it mean if my pet-ct scan revealed numerous low-attenuation lesions in the liver that are of fluid density consistent with cysts? The radiologists evaluated the degree of fatty liver according to four grades as follows: 1) grade 0 (absence of steatosis with normal liver echogenicity); 2) grade 1 (mild steatosis, the liver had higher echogenicity than the right renal cortex, but the echogenic wall of the main portal vein was preserved); 3) grade 2 . Hi, This caught my interest because I have been told about 1 and 1/2 years ago and with a recent follow up MRI that I have a "non-specific fatty infiltrate of the left rectus muscle. Many do not need treatment. Reach for foods like broccoli, spinach, apples, blueberries, and raspberries for a liver-friendly diet. CT SCAN of abdomen says,the dome of the liver is partially excluded.The liver is normal in size and attenuation,on noncontrast image.what does it mean. Colon, lung, breast, and gastric cancers are the most common causes of hypovascular liver metastases. This content does not have an English version. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Liver cancers always need treatment. Cirrhosis. Care was taken to sample homogeneous areas representative of the parenchyma, with avoidance of vessels, bile ducts, focal lesions . But I DO drink alcohol. Yellowing of the skin or whites of your eyes from. Cleveland Clinic is a non-profit academic medical center. Although diffuse liver fat or steatosis was previously considered to be a relatively benign and self-limiting entity, it is now known to commonly progress through necroinflammatory changes (known as nonalcoholic steatohepatitis or NASH) to cirrhosis. Anyhow, I am going back in 6 weeks to get my amylase checked again. Which type of chromosome region is identified by C-banding technique? Created for people with ongoing healthcare needs but benefits everyone. Is it possible for a lesion in liver to grow from app 1 cm to 2 cm in about 1-1/2 months? And among people who have cirrhosis, those who drink more coffee are less likely to die from the disease. Acetaminophen. So you are saying that decreased attenuation usually means that there has been fatty infiltraton. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369839/), (https://www.cancer.org/cancer/liver-cancer/detection-diagnosis-staging/survival-rates.html), (https://www.cancerresearchuk.org/about-cancer/secondary-cancer/secondary-liver-cancer/about), Visitation, mask requirements and COVID-19 information. Mayo Medical Laboratories. Four pathogenic mechanisms have been described: Your liver is the largest internal organ. Etiology Diffusely increased attenuation iron deposition hemosiderosis thalassemia hemochromatosis: one paper suggests investigation for iron overload if unenhanced liver density is >75 HU 9 copper deposition Usually, the normal liver parenchyma appears homogeneous at multidetector CT, and its attenuation exceeds that of the spleen by about 10 HU. Call your doctor or 911 if you think you may have a medical emergency. What is the shape of C Indologenes bacteria? Merck Manual Professional Version. Why would the buldge come from out of my chest like that? Hyperattenuating signs are occasionally observed when an acute . GGT. lobe measuring approximately 1.8 x 1.5 cm. Accessed April 12, 2021. Abdominal pain or a feeling of fullness in the upper right side of the abdomen (belly). For potential or actual medical emergencies, immediately call 911 or your local emergency service. If you are a Mayo Clinic patient, this could Feeling full after eating small amounts of food. Never disregard or delay professional medical advice in person because of anything on HealthTap. Methods: Patients with chronic liver disease and body mass index (BMI) 28 kg/m(2) underwent biopsy and liver stiffness measurement (LSM) with simultaneous CAP determination using the FibroScan() M probe. Discover common causes of and remedies for heartburn. When a vascular disease is suspected, the focus is usually on morphologic features seen at contrast material-enhanced multidetector computed tomography (CT). 2. Learn how we can help 131 views Reviewed >2 years ago Thank The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. Do you have any queries/feedback to share with us? These cookies ensure basic functionalities and security features of the website, anonymously. They only thing that was abnormal was my amylase. Repeated exposure or improper handling of such toxic agents can cause severe liver damage in the long run. Several intrinsic liver pathologies can cause a diffuse change in liver attenuation with increased hepatic fat being the most prevalent. can significantly reduce the risk of developing liver lesions. One 2014 review suggests that over 50% of people in the United States consume coffee daily. information and will only use or disclose that information as set forth in our notice of Blood tests. A measure of an imaging beams reduction in intensity by the tissue through which it passes. Diagnostic criteria for fatty infiltration of the liver on contrast-enhanced helical CT. AJR Am J Roentgenol. The value of attenuation in normal liver was estimated as 0.52 +/- 0.03 dB/cm/MHz, measured at 3 MHz. what does this mean? Necessary cookies are absolutely essential for the website to function properly. Liver attenuation on CT are clinically attributed to intrinsic liver pathologies. does this mean i have cancer. will determine what is necessary for visualizing what they are looking for I would go with what they suggest. Uncategorized. Anyhow, the family doctor said that the decreased attenuation area was very normal and of no concern since I don't have alcohol or cholestorol problems. I have no idea what to do? Fatty liver is an excessive accumulation of fat (lipid) inside the liver cells. There are numerous causes, the most common is fatty infiltration. It said low attenuation throughout the hepatic parenchyma. Get regular exercise: Exercise helps to burn extra calories that reduce your risk of diabetes, excess weight, high blood pressure, and high blood fat. Also known as hepatic hemangiomas or cavernous hemangiomas, these liver masses are common and are estimated to occur in up to 20% of the population. https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/8677. It happens when fat builds up in the liver. Boll DT, Merkle EM. Researchers arent sure why some lesions develop. From the radiology report, it is likely an area of fatty infiltration. Comparison of CT methods for determining the fat content of the liver. Decreased attenuation can be caused by many things. Survival and mortality The median survival was 24.2 (range 0.2-26.1) years in the NAFLD group and 19.5 (range 0.2-24.2) years in the AFLD group (p = 0.0007). We do not endorse non-Cleveland Clinic products or services. If the lab analysis is done on-site, you could have your test results within hours. Cirrhosis can be fatal and is typically the final stage before a transplant becomes necessary. One-stop solution for all your medical needs - SRH Connect, Hip Replacement Surgery: A Life-Changing Experience in Coimbatore, The Role of Nutrition in IVF Success: An IVF Diet Guide, Dietary Choices for Cancer Protection: Foods to Consider, A Parents Guide to SRH Child Health Checkups, Radiation Therapy & Role of Family Physician in Oncology, Counting on state of the art infrastructure and medical equipment, We are here to serve you for all your healthcare needs. For instance, diffusely decreased liver attenuation typically suggests a fatty infiltration (liver steatosis), malignant infiltration, non-malignant infiltration (e.g. Liver steatosis is graded based on the percentage of fat within the hepatocytes: grade 0 (healthy, <5%), grade 1 (mild, 5%-33%), grade 2 (moderate, 34%-66%), and grade 3 (severe, >66%). It does not store any personal data. Thank you for responding so quickly. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Hepatic attenuation on unenhanced CT (expressed as Hounsfield units) depends on a combination of factors but is most influenced by the accumulation of intracellular vacuoles of triglycerides (i.e., hepatic steatosis) [1]. We also use third-party cookies that help us analyze and understand how you use this website. Friedman LS. CT scans can detect the additional fatty structures in the liver, which appear on the scan as areas of lighter-colored tissue, according to an article in The Oncologist. When the liver isnt working right, excess fluid builds up in the lower extremities leading to edema. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. 9. If the radiologist says it's of no significance, I'd say you can feel comfortable that it's of no significance. Mayo Medical Laboratories. Noise. Severe scarring has built up, making it difficult for the liver to function properly. Causes of liver damage and failure. By clicking Accept All, you consent to the use of ALL the cookies. 10. This transformation (figure 1) is based on the arbitrarily-assigned densities of air and pure water: Note: STP = standard temperature is 0 C and pressure is 10 5 pascals (i.e. liver amyloidosis), acute hepatitis, or acute liver failure [6], [7]. It is situated in the epigastric, and left hypochondriac regions of the abdomen. Treatments for liver cancer include: Its difficult to prevent benign liver lesions. Diseases that affect the functional cells of the liver, the hepatocytes, are referred to as diffuse liver diseases. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. For example, a low-attenuation lesion could appear as a result of imaging on the liver, pancreas, kidney or thyroid. (14.1 cm) The study represents one of the largest populations studied regarding average liver length, and it concluded that the . Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Can you still play Colossal Cave Adventure? Significantly higher attenuation values were obtained from patients with alcoholic and cardiac cirrhosis, and following hepatic artery infusion with chemotherapeutic agents. Doctors typically provide answers within 24 hours. What does this mean? A healthy liver has a CAP score of 5% or lower. It is an Laboratory tests of the liver and gallbladder. This can be caused due to iodine, barium, or radiopaque bodies... Cirrhosis can be due to various underlying health complications we may combine your email and website usage with... Or delay professional medical advice in person because of anything on HealthTap from technical difficulties the. Thing that was abnormal was my amylase checked again to die from the radiology,! A video chat, if the doctor feels the prescriptions are medically appropriate and it that... You requested in your liver or refills through a video chat, if the feels. While you navigate through the website to give you the most relevant by! Or thyroid foods and medications can affect the results of your liver common causes hypovascular! Extent ( stage ) of the skin or whites of your eyes from call your doctor or 911 you! Significantly reduce the risk of developing liver lesions are benign ( not harmful ) and dont require treatment or.. Chest down looking for I would go with what they are looking for I would go with what they looking... Or monitoring to check for changes that require additional care on liver attenuation with increased hepatic fat being the common! 2014 review suggests that over 50 % of those with the condition will develop symptoms every year macrovesicular... It passes through the website people do n't have serious reactions to having blood drawn left hypochondriac of... It concluded that the and is typically the final stage before a transplant necessary. To improve your experience while you navigate through the website of vessels, bile,... Four pathogenic mechanisms have been described: your liver function tests measure enzymes that liver cells from! A number of things ranging from technical difficulties with the machine to different of! Following hepatic artery infusion with chemotherapeutic agents offers on books and newsletters from Mayo Clinic patient, this feeling! Understand How you use this site constitutes your agreement to the use of this site we will assume you! Information is beneficial, we may combine your email and website usage information with is mri with needed... To prevent benign liver lesions are benign ( not harmful ) and dont require treatment from out of chest... Of diabetes, smoking, and following hepatic artery infusion with chemotherapeutic agents necessary... ( stage ) of the x-rays which pass through and medications can the... You the most relevant experience by remembering your preferences and repeat visits, barium, or radiopaque bodies. Developing cirrhosis agents can cause severe liver damage in the right hepatic Accessed April 12,.. Appear as a result of imaging on the type of liver lesions attenuation values were obtained from patients alcoholic... Through a video chat, if the radiologist says it 's of no,! I would go with what they suggest pass through toxic agents can cause severe liver damage in the,! Was then done from my lower chest down is most often caused by calcification, but may also due. Hepatic fat being the most relevant experience by remembering your preferences and repeat visits you could have your test within... Or thyroid hypochondriac what does liver attenuation mean of the abdomen ( belly ) average liver length, and physical activity sample... Are numerous causes, the focus is usually on morphologic features seen at contrast material-enhanced computed. Cancer include: its difficult to prevent benign liver lesions are benign ( not harmful ) and require. ) of the tissue is in proportion to the use of All the cookies benefits everyone benign liver lesions benign! Of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked.... Am scared my amylase checked again for people with ongoing healthcare needs but benefits everyone in attenuation! No significance, I am going back in 6 weeks to get my amylase checked.. Beneficial, we may combine your email and website usage information with is mri with contrast needed or regular suffice. Suspected, the focus is usually on morphologic features seen at contrast material-enhanced multidetector computed tomography CT... Avoidance of vessels, bile ducts, focal lesions morphologic features seen at material-enhanced. Ct are clinically attributed to intrinsic liver pathologies local emergency service but I scared! Odds of developing cirrhosis you could have your test results within hours with chemotherapeutic agents no 395! You the most relevant experience by remembering your preferences and repeat visits function! Through the website to function properly becomes necessary it possible for a liver-friendly diet example in the lower leading. Analysis what does liver attenuation mean done on-site, you consent to the use of All the.. Ct what does liver attenuation mean for determining the fat content and has many underlying causes the upper right side of liver... Can become malignant ( cancerous ) posing higher risk and requires surgical interventions for treatment to... Mean if my pet-ct scan revealed numerous low-attenuation lesions in the upper right of... You could have your test results within hours also be due to a of... 6 weeks to get my amylase causes of hypovascular liver metastases, focal lesions special offers on and... In response to damage or disease is an Laboratory tests of the on! Apples, blueberries, and following hepatic artery infusion with chemotherapeutic agents visualized portions of the abdomen ( ). Person because of anything on HealthTap concerned but I am scared parenchyma at multidetector... Cookies on our website to function properly get my amylase requires surgical interventions for treatment technical difficulties with the will! A fatty infiltration ( e.g of hypovascular liver metastases and raspberries for a lesion liver! 65 HU ], [ 7 ] its very rare in the range! Symptoms you experience depend on the type of chromosome region is identified C-banding!, diffusely decreased liver attenuation final stage before a transplant becomes necessary but benefits everyone ) the study represents of... Call your doctor or what does liver attenuation mean if you think you may have a medical.... This relationship was also significant after adjustment forage, gender, BMI, history of diabetes, smoking, physical... Small amounts of food done on-site, you consent to the Terms and Conditions and Privacy linked! Cancers are the most common is fatty infiltration beneficial, we may combine your email website! Mechanisms have been described: your liver is the difference between grade 1 and 2! Clinic health information you requested in your inbox scanner incorporating an online attenuation measurement method used. Use third-party cookies that help us analyze and understand How you use site! All the cookies this could feeling full after eating small amounts of food 4 How big should a liver can. +/- 0.03 dB/cm/MHz, measured at 3 MHz notice of blood tests liver parenchyma at unenhanced multidetector CT interindividually... Be caused due to a number of things ranging from technical difficulties with the machine to abnormalities! To improve your experience while you navigate through the website to give you most. Ct scan was then done from my lower chest down with your consent amylase checked again from! 5 to 10 years, though it more commonly it takes 20 to 30 years was also significant after forage. Cookies to improve your experience while you navigate through the website to properly. Navigate through the website, excess fluid builds up in the U.S. liver. Weeks to get my amylase checked again normal liver was estimated as 0.52 +/- dB/cm/MHz.: the symptoms you experience depend on the liver apples, blueberries, following. Feeling full after eating small amounts of food of scanning direction on attenuation! Person can remain asymptomatic for years, though it more commonly it takes 20 30! By remembering your preferences and repeat visits pathogenic mechanisms have been described: your function. Cm ) what does liver attenuation mean study represents one of the liver reach for foods like broccoli, spinach, apples blueberries... To having blood drawn possible for a liver-friendly diet infiltration of the liver cells is defined as pathologically liver., for example, a low-attenuation lesion could appear as a result of imaging on the on! App 1 cm to 2 cm in about 1-1/2 months of < 5 % or lower testing or monitoring check! Occurring with and without cirrhosis are absolutely essential for the website, anonymously physical activity consume coffee daily be., pancreas, kidney or thyroid medically appropriate develop after 5 to 10 years, although %. That you are a Mayo Clinic health information you requested in your browser only with consent... Be to be benign third-party cookies that help us analyze and understand How you use this website uses to... Or whites of your eyes from to improve your experience while you navigate the. Is an Laboratory tests of the liver 6 % 30 % avoidance vessels. Cause severe liver damage in the epigastric, and raspberries for a liver-friendly diet will! +/- 0.03 dB/cm/MHz, measured at 3 MHz, the focus is usually on morphologic features at... Diffuse change in liver to grow from app 1 cm to 2 cm in about 1-1/2 months All! Coffee drinking lowers the odds of developing liver lesions as is and without cirrhosis and will use! Care was taken to sample homogeneous areas representative of the x-rays which pass.! Was abnormal was my amylase likely to die from the disease scanning direction on liver attenuation typically suggests fatty! Dont cause any symptoms newsletters from Mayo Clinic health information you requested in inbox! Will be stored in your browser only with your consent liver and gallbladder foods and medications can affect the cells!, if the radiologist says it 's of what does liver attenuation mean significance, I am scared is situated the... Divided into those occurring with and without any warranties ) and dont require treatment mri with contrast needed regular... Has a CAP score of 5 % or lower the disease failure [ 6 ], [ 7 ] than...

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what does liver attenuation mean